Metabolism is the process of converting the food you eat into energy needed for day-to-day living and into the building blocks your body uses for growth and repair. It also includes the elimination of waste materials generated in the body. A metabolism is considered healthy when it generates enough energy, digests food well, produces healthy levels of fats (cholesterol) and sugars (glucose) in the bloodstream and maintains a healthy body composition.
A healthy metabolism is determined by both intrinsic factors (organs, cells, gene variations etc.) and extrinsic factors (foods, drinks, environment etc.) that may assist with energy metabolism. Hormones and enzymes also play a crucial role in metabolism. There is an intricate relationship between the hormones, intrinsic and extrinsic factors as one affects the other.
Metabolic disease symptoms may include low energy levels, poor blood glucose control, high cholesterol, cravings, and poor digestion. However, all the systems in your body can eventually become affected by a poor metabolism because they rely on it for energy production and for the essential building blocks required to make hormones, muscles, cells and much more.
Everyone is unique and thus, there is no secret recipe to magically transform the metabolism into a Ferrari, but, following a healthy diet, managing stress, being active and ensuring good quality sleep are crucial to metabolic health. In addition, certain supplements may assist in optimising the metabolism by regulating blood sugars, blood lipids, inflammation and energy production.
Berberine is shown in numerous studies to support healthy blood sugar, blood pressure and blood lipid levels, and overall general health.
Coyne Bio-Berberine® Advanced contains 500mg pure Berberine Hydrochloride, as well as 125mg Origine 8® green tea extract and 25mcg chromium. These additional ingredients may further enhance the potency of this product by improving insulin sensitivity and enhancing protein, carbohydrate and lipid metabolism.
Berberine has many benefits. In fact, clinical studies show that it may reduce “bad” LDL-cholesterol without also decreasing the “good” HDL-cholesterol (Bertuccioli, et al. 2020).
A review of 12 different clinical studies also showed that Berberine reduced body weight, BMI and waist circumference significantly. The same review even showed that C-reactive protein was significantly reduced by berberine supplementation (Asbaghi, et al. 2020). C-Reactive protein is a measurement of inflammation in the body and is usually high when there is metabolic dysfunction.
In another review which included 5 clinical studies the researcher concluded that Berberine assisted in lowering chronic inflammation in metabolic disease (Beba, et al. 2019).
Berberine may reduce insulin resistance (Ye, et al. 2021) and has been compared to pharmaceutical medications in some clinical trials where it shows that they have equal efficacy (Wang, et al. 2017).
In addition, green tea extract provides multiple benefits for metabolic health through its anti-inflammatory and antioxidant properties (Esmaeelpanah, et al. 2021). Origine 8® green tea extract may provide these benefits.
Coyne Biomax® Vitamin B Complex Liposomal is a complete vitamin B supplement with liposomal technology ensuring enhanced bioavailability and absorption. It contains Quatrefolic® – a natural, concentrated form of vitamin B9, known as folic acid, which is an essential nutrient. B vitamins may contribute to and assist with normal energy metabolism, normal function of the nervous system, mental performance, metabolism of carbohydrates, proteins and fats, normal growth and development, and maintenance of good health.
Many of the B vitamins are necessary for the process of converting the food we eat into energy, so, in order to ensure proper metabolic function it is essential to ensure that adequate B vitamins are consumed (Woolf & Manore, 2006).
Curcumin is the most active constituent of turmeric and an incredibly potent botanical. Proven to support a healthy inflammatory response, this compound modulates inflammation and its damaging effects (Hewlings & Kalman, 2017).
Bio-Curcumin® BCM95® uses market-leading BCM-95™ curcumin, a combination of 95% curcumin and AR-turmerone (the essential oil naturally found in turmeric root). This powerful combination of actives found in the rhizomes of turmeric has been shown to greatly enhance the bioavailability and activity of curcumin (Antony, et al. 2008).
Recent clinical evidence has shown that curcumin not only has benefits for the increased inflammation that is common with metabolic disease, but it may also directly assist with multiple metabolic diseases including polycystic ovarian syndrome, metabolic syndrome and non-alcoholic fatty liver disease (Jabczyk, et al. 2021).
|1. Antony, B., Merina, B., Iyer, V. S., Judy, N., Lennertz, K., & Joyal, S. (2008). A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian journal of pharmaceutical sciences, 70(4), 445–449. Available from: https://www.ijpsonline.com/articles/a-pilot-crossover-study-to-evaluate-human-oral-bioavailability-of-bcm95-cg-biocurcumaxtm-a-novel-bioenhanced-preparation-of-curcum.html|
|2. Asbaghi, O., Ghanbari, N., Shekari, M., Reiner, Ž., Amirani, E., Hallajzadeh, J., Mirsafaei, L., & Asemi, Z. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical nutrition ESPEN, 38, 43–49. https://doi.org/10.1016/j.clnesp.2020.04.010|
|3. Beba, M., Djafarian, K., & Shab-Bidar, S. (2019). Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials. Complementary therapies in medicine, 46, 81–86. https://doi.org/10.1016/j.ctim.2019.08.002|
|4. Bertuccioli, A., Moricoli, S., Amatori, S., Rocchi, M. B. L., Vici, G., & Sisti, D. (2020). Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules-A Meta-Analysis. Journal of medicinal food, 23(2), 101–113. https://doi.org/10.1089/jmf.2019.0088|
|5. Esmaeelpanah, E., Razavi, B. M., & Hosseinzadeh, H. (2021). Green tea and metabolic syndrome: A 10-year research update review. Iranian journal of basic medical sciences, 24(9), 1159–1172. https://doi.org/10.22038/IJBMS.2021.52980.11943|
|6. Hewlings, S., & Kalman, D. (2017). Curcumin: A Review of Its Effects on Human Health. Foods 2017, 6(10), 92. https://doi.org/10.3390/foods6100092|
|7. Jabczyk, M., Nowak, J., Hudzik, B., & Zubelewicz-Szkodzińska, B. (2021). Curcumin in Metabolic Health and Disease. Nutrients, 13(12), 4440. https://doi.org/10.3390/nu13124440|
|8. Wang, H., Zhu, C., Ying, Y., Luo, L., Huang, D., & Luo, Z. (2017). Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget, 9(11), 10135–10146. https://doi.org/10.18632/oncotarget.20807|
|9. Woolf, K., & Manore, M. M. (2006). B-vitamins and exercise: does exercise alter requirements?. International journal of sport nutrition and exercise metabolism, 16(5), 453–484. https://doi.org/10.1123/ijsnem.16.5.453|
10. Ye, Y., Liu, X., Wu, N., Han, Y., Wang, J., Yu, Y., & Chen, Q. (2021). Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Frontiers in pharmacology, 12, 653887. https://doi.org/10.3389/fphar.2021.653887