The Relationship Between Sulforaphane and Hormonal Balance 

Oestrogen is a crucial hormone that regulates many functions in the body, from reproductive health to mood and metabolism. However, when oestrogen levels become imbalanced, or when the body has difficulty properly metabolising and detoxifying excess oestrogen, it can lead to various health issues, including a hormonal imbalance due to oestrogen dominance. [8]  

What is Sulforaphane?  

Sulforaphane is a phytochemical compound derived from cruciferous vegetables, specifically broccoli sprouts. It plays a crucial role in regulating the activity of antioxidant proteins, protecting the body against free radicals that can cause oxidative stress and cell damage. Sulforaphane promotes detoxification and may help reduce inflammation and promote the protection of DNA. [6] 

What is Oestrogen Dominance?  

Oestrogen dominance occurs when oestrogen levels are elevated relative to progesterone, even if oestrogen levels are within a normal range, and can be a result of stress, poor liver detoxification, hormonal medications, or other hormonal conditions. [7] 

 Symptoms of oestrogen dominance may include:  

• Menstrual changes such as irregular, heavy, or light periods. 

• Mood changes including anxiety, irritability, and mood swings. 

• Physical symptoms such as breast tenderness, water retention, weight gain, and bloating. 

• Increased skin conditions and hair loss. 

• Fatigue and trouble concentrating.  

• Decreased libido. [7] 

How Does Oestrogen Detoxification Work? 

Oestrogen detoxification is a multi-step process that takes place primarily in the liver. The body metabolises oestrogen through three key phases. When these processes are impaired, oestrogen can accumulate in the body, increasing the risk of oestrogen dominance and associated conditions like PMS and endometriosis [9]. These three key phases of detoxification are: 

1. Phase I Detoxification: In this phase, oestrogen is broken down into metabolites by liver enzymes known as cytochrome P450 enzymes. The metabolites produced can be either beneficial or harmful, depending on how they are processed. 

2. Phase II Detoxification: The harmful oestrogen metabolites undergo conjugation reactions, such as methylation, sulfation, or glucuronidation. This transforms the metabolites into water-soluble forms, making it easier for the body to excrete them through urine or stool. 

3. Phase III Detoxification: This final phase involves the actual excretion of these metabolites from the body. Poor excretion can lead to the reabsorption of oestrogen, contributing to hormone imbalances [1]. 

How Sulforaphane Supports Oestrogen Detoxification and Hormonal Balance 

Sulforaphane is known for its ability to upregulate enzymes involved in phase II detoxification, such as glutathione S-transferase (GST) and UDP-glucuronosyltransferase (UGT). These enzymes play a critical role in converting harmful oestrogen metabolites into water-soluble compounds, making it easier for the body to eliminate them. By enhancing phase II detoxification, sulforaphane may help prevent the buildup of harmful oestrogen byproducts that could otherwise increase the risk of oestrogen-related conditions and hormonal imbalance.  

Sulforaphane is a potent activator of Nrf2, a transcription factor that increases the body’s production of antioxidant enzymes, including glutathione, a master antioxidant and a crucial player in phase II detoxification. These enzymes can bind to to harmful oestrogen metabolites, neutralising them and facilitating their excretion. 

Sulforaphane also helps protect against xenoestrogens, which are oestrogen-like compounds found in the environment. These synthetic chemicals, present in plastics, pesticides, and personal care products, can mimic oestrogen in the body, leading to hormone disruption. Sulforaphane’s ability to activate detoxification pathways helps the body eliminate these harmful xenoestrogens, reducing their impact on hormonal health [2] [10]. 

Other Health Benefits of Sulforaphane 

In addition to its role in oestrogen detoxification, sulforaphane offers a wide range of health benefits. It is a potent antioxidant and anti-inflammatory that can help enhance the body’s natural defenses against oxidative stress. This protects cells from damage and reduces inflammation, which can support the prevention of chronic health challenges. Sulforaphane has also been shown to promote the elimination of carcinogens.

Additionally, sulforaphane may support brain health by protecting neurons from damage due to its support for the prevention of inflammation and oxidative stress. Sulforaphane may also have the potential to improve gut health as it influences the gut microbiota by promoting the growth of beneficial bacteria. A healthy balance of gut bacteria is essential for proper digestion, nutrient absorption, and immune function. Sulforaphane helps maintain the integrity of the gut barrier, preventing harmful substances from leaking into the bloodstream [3]. 

What is the Best Way to Take Sulforaphane? 

One can get sulforaphane from their diet by consuming cruciferous vegetables such as broccoli (most concentrated in broccoli sprouts), cauliflower, and kale [4]. Another way to increase your sulforaphane intake is to include a high-quality supplement in your regimen. Coyne Biomax® Bio-Sulforaphane Advanced is a highly bioavailable and concentrated source of broccoli phytonutrients, specifically rich in sulforaphane.

This compound plays a crucial role in regulating the activity of antioxidant proteins, providing protection against free radicals that can cause oxidative stress. By promoting detoxification, Biomax® Bio-Sulforaphane Advanced supports the body’s natural processes to eliminate toxins and maintain overall health. A therapeutic dose of sulforaphane ranges from 1.1- 9 mg depending on an individual’s weight [5]. This would equate to eating about 100 grams (or a full cup) of broccoli per day. Biomax® Bio-Sulforaphane Advanced offers 7 mg of sulforaphane per dose / 1 capsule. 

Remember to always consult a healthcare practitioner before starting a new supplement regimen.