Longevity supplements are nutritional supplements intended to promote health and wellness, and potentially extend lifespan. They often include a variety of nutrients and extracts to support cellular function, combat ageing, and enhance overall vitality.
Benefits of Longevity Supplements
Enhanced Cellular Health: Supplements like NAD+ boosters and CoQ10 support cellular function and repair, crucial for overall health.
Healthy-Ageing Effects: Antioxidants such as resveratrol and curcumin can reduce visible signs of ageing by protecting cells from oxidative stress.
Improved Vitality and Energy: Omega-3 fatty acids and NAD+ boosters enhance mitochondrial function, leading to increased energy and reduced fatigue.
Enhanced Cognitive Function : Omega-3s and resveratrol support brain health, potentially improving memory and mental clarity.
Improved Cardiovascular Health : Supplements such as omega-3s, CoQ10, and resveratrol have positive effects on heart health by reducing inflammation and improving cholesterol levels. Heart health is a significant concern as we age, and several longevity supplements can support cardiovascular function.
Supplements to Promote Longevity
There are several popular types of longevity supplements, each with their own unique benefits:
- NAD+ boosters: Nicotinamide adenine dinucleotide (NAD+) is a coenzyme critical for cellular energy production and repair. Supplements such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are commonly used to increase NAD+ levels. NAD+ levels are responsible for the transfer of electrons from one molecule to another within the body’s cells, carrying out metabolic reactions to generate cellular energy, and promote DNA repair and mitochondrial health. [1] NAD+ is crucial for human health and longevity as it plays a critical role in various biological processes, including metabolism and gene expression. It also regulates homeostasis, a state of balance amongst all bodily functions needed for survival, which protects the cells from age-related decay and is, therefore, a necessary component of longevity and healthy ageing. [2] Try Phytoceutics® Phytopure® NMN + Fisetin Advanced containing Uthever®, a patented form of NMN, which has been clinically tested on humans.
- Resveratrol: Resveratrol is a polyphenol found in grapes, and is widely known for its antioxidant properties, protective against cardiovascular diseases, inflammation, and cancer, therefore promoting longevity. Resveratrol activates Sirtuin 1 (SIRT1), an NAD+-dependent protein deacetylase that is known to halt the cell cycle and induce DNA repair, slow down apoptosis (a type of cell death), regulate premature cell senescence and diminish endothelial senescence and vascular ageing. [3] It is also responsible for reducing age-related diseases, decreasing the rate of ageing, and increasing life expectancy. Try Phytoceutics® Reversatrol™ which utilises ResveraFen™ and Hybrid-FENUMAT™ technology, achieving a tenfold increase in resveratrol absorption and bioavailability.
- Omega-3 fatty acids: These crucial fats, typically found in fish oil, are recognised for their anti-inflammatory effects and their positive impact on heart and brain health. High levels of DHA (docosahexaenoic acid), an omega-3 fatty acid, have been associated with a lower risk of overall mortality and deaths caused by cardiovascular diseases, thus increasing life expectancy. [4] Recent research has shown that individuals with higher omega-3 blood levels lived longer than people with lower levels, with an increased life expectancy of 4.7 years. [5] Research has also shown that individuals with higher omega-3 levels also had a significantly lower risk of cardiovascular events such as heart attacks and strokes. [6] Try Coyne Purest Omega 3 containing both EPA and DHA omega-3 fatty acids, derived from sustainably caught wild Alaskan pollock which boasts a leading TOTOX score
- Coenzyme Q10 (CoQ10): Coenzyme Q10, also known as ubiquinone, is an enzyme synthesized naturally by the body. CoQ10 works by stimulating our cell’s mitochondria to produce energy in the form of adenosine triphosphate (ATP), and, therefore, helping the body convert food into energy more efficiently. Furthermore, CoQ10 works as an antioxidant in both the mitochondria and cell membranes, thereby helping to prevent cellular damage. One of the proposed theories of ageing is a decline in energy metabolism, in which CoQ10 has an important role. In a small randomized controlled trial, older adults were given CoQ10 daily for four years.[8] Results showed improvements in vitality, physical performance, and overall quality of life, and after a twelve-year follow-up, participants also displayed reduced cardiovascular mortality compared to the placebo group. [9] Additional research exists regarding CoQ10’s effect on glucose levels—results of such studies show a low dose of the enzyme (around 10mg) can improve markers associated with diabetes, including glucose and HbA1c levels, which may impact longevity. [7] Try Coyne Biomax® PQQ with CoQ10 containing highly bioavailable BioPQQ® and MicroActive® CoQ10 featuring a 24-hour sustained release formula
- Curcumin: Curcumin is a polyphenol found in the root of the turmeric plant. It possesses powerful anti-inflammatory and antioxidant properties that can promote joint health and overall well-being. Curcumin reduces oxidative stress, modulates signal transduction, and can regulate gene expression, promoting longevity. Curcumin has antioxidant characteristics, functions as a biochemical antioxidant, and can regulate cellular defenses. Researchers have discovered that curcumin combats several key factors of ageing; studies show that curcumin helps eliminate senescent cells. In one animal study, curcumin was seen to extend the average lifespan by 26%. As cells age, they generally die off and make room for new healthy cells, however, some do not. These cells accumulate damage and enter a state known as senescence, a major contributor to ageing and age-related diseases. Studies show that curcumin and its metabolites have senolytic activity (the elimination of senescent cells); in one study on mice, curcumin was able to decrease the number of senescent cells to a normal level, thus extending their lifespan. [8] Try Coyne Bio-Curcumin® with BCM-95® which leverages a patented formulation for improved absorption, resulting in a sevenfold increase in bioavailability compared to regular curcumin supplements.
Who Should Consider Taking Longevity Supplements?
Longevity supplements are suitable for a variety of people. Ageing adults may use them to support cellular health and vitality. Those with nutrient deficiencies might take these supplements to address specific gaps in their diet. Individuals with particular health goals, such as athletes or those seeking cognitive enhancement, can benefit from targeted supplements. Health-conscious individuals looking to prevent age-related decline and promote long-term well-being are also ideal candidates. Additionally, people experiencing high levels of stress may find these supplements helpful in managing their stress and improving resilience.
Lifestyle and Dietary Practices to Promote Longevity
Adopting a balanced lifestyle and mindful nutrition are fundamental to promoting longevity and healthy ageing. Individuals should include a diet rich in nutrient-dense foods, including fruits, vegetables, whole grains, lean proteins, and healthy fats, to provide essential vitamins, minerals, and antioxidants. Regular physical activity, such as aerobic exercises, strength training, and flexibility routines, supports cardiovascular health, muscle maintenance, and overall vitality. Adequate sleep is crucial for cellular repair and cognitive function, while stress management techniques such as mindfulness, meditation, or hobbies can help maintain emotional balance. By integrating these practices into your daily routine, you can create a holistic approach to ageing that supports both physical and mental health. [9]
Incorporating longevity supplements into your health regimen can be a valuable strategy for enhancing well-being and potentially extending vitality and even life expectancy. As you navigate this choice, it’s important to evaluate your individual health needs, consider the scientific evidence supporting these supplements, and consult with healthcare professionals to make an informed decision. Remember that supplements should complement, not replace, a balanced lifestyle that includes proper nutrition, regular exercise, and stress management. By integrating longevity supplements thoughtfully, you can support your long-term health and wellness goals more effectively.
References
1. NAD.com. What is NAD? [Internet]. Available from: https://www.nmn.com/precursors/what-is-nad
2. Effect Doctors. NAD: Everything you need to know [Internet]. Available from: https://effectdoctors.com/blog/nad-everything-you-need-to-know/
3. ScienceDirect. Sirtuin 1 (SIRT1) [Internet]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/sirtuin-1#:~:text=Sirtuin%201%20(SIRT1)%20is%20an,endothelial%20senescence%20and%20vascular%20aging.
4. Saint Luke’s Health System. Higher omega-3 levels associated with improved life expectancy [Internet]. Available from: https://www.saintlukeskc.org/about/news/higher-omega-3-levels-associated-improved-life-expectancy
5. McBurney, M.I. et al. (2021) Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: The Framingham offspring cohort, The American Journal of Clinical Nutrition, 114(4), pp. 1447–1454. doi:10.1093/ajcn/nqab195.
6. Harris, W.S. et al. (2018) Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart Study, Journal of Clinical Lipidology, 12(3). doi:10.1016/j.jacl.2018.02.010.
7. InsideTracker. The evidence behind resveratrol and CoQ10’s effects on aging [Internet]. Available from: https://www.insidetracker.com/a/articles/the-evidence-behind-resveratrol-and-coq10s-effects-on-aging#
8. Life Extension. Curcumin: Anti-aging [Internet]. Available from: https://www.lifeextension.com/magazine/2021/ss/curcumin-anti-aging
9. Drip Hydration. Longevity and wellness. Available from: https://driphydration.com/blog/longevity-wellness/
